NAD+ injections work by delivering nicotinamide adenine dinucleotide directly into the bloodstream, bypassing the digestive system to ensure maximum absorption at the cellular level. This replenishes the body's supply of NAD+, a vital coenzyme, to power cellular functions and address age-related decline.

Biological Functions

• Energy Metabolism: Essential cofactor in glycolysis, citric acid cycle, and oxidative phosphorylation
• DNA Repair: Required for poly(ADP-ribose) polymerase (PARP) enzymes that repair DNA damage
• Sirtuin Activation: Serves as substrate for sirtuin enzymes (longevity proteins) that regulate aging processes
• Cellular Signaling: Involved in calcium signaling and cyclic ADP-ribose production
• Circadian Rhythm: Plays a role in maintaining cellular circadian clocks
• Mitochondrial Function: Critical for mitochondrial biogenesis and function

Natural Decline:

• NAD+ levels decrease by ~50% between ages 40-60
• Reduced NAD+ biosynthesis enzymes
• Increased NAD+ consumption by DNA repair enzymes
• Decreased efficiency of mitochondrial respiration

The Devastating Effects:

• Chronic fatigue and low energy
• Impaired DNA repair capacity
• Decreased sirtuin activity
• Mitochondrial dysfunction
• Accelerated aging and disease risk

The Aging Crisis:

By age 50, you have half the NAD+ you had at 20. This dramatic decline is directly linked to why you feel older, tire easier, and struggle with the energy you once had.

Metabolic Revival:

• Dramatically improved energy levels
• Enhanced fat burning and metabolism
• Better glucose control
• Increased exercise capacity
• Natural weight management support

Anti-Aging Miracles:

• Activated longevity pathways
• Enhanced DNA repair
• Improved skin health and appearance
• Slower cellular aging
• Increased lifespan potential

Clinical Breakthrough:

Harvard studies show that boosting NAD+ can reverse aspects of aging in human cells, with participants reporting 60% increases in NAD+ levels and dramatic improvements in energy and vitality.

Human Studies:

• Nicotinamide riboside supplementation increased NAD+ levels by 60% in healthy adults
• Improved insulin sensitivity in prediabetic individuals
• Enhanced mitochondrial function in older adults
• Potential cardiovascular benefits in small trials

Preclinical Research:

• Extended lifespan in various animal models
• Improved cognitive function and neuroprotection
• Enhanced muscle function and exercise capacity
• Protection against age-related metabolic decline

Generally Well-Tolerated:

• NAD+ is naturally occurring in the body
• Minimal side effects in clinical trials
• No serious adverse events reported
• Safe profile in healthy adults

Mild Side Effects:

• Mild nausea (with high oral doses)
• Flushing (with IV administration)
• Fatigue (rare, usually temporary)
• Headache (uncommon)

Subcutaneous:

• Good bioavailability
• Self-administration possible
• Lower doses than oral
• Gradual absorption

• Individual Response: Effects may vary based on baseline NAD+ levels and individual metabolism
• Timing: Some evidence suggests morning administration may be optimal for circadian rhythm support
• Lifestyle Factors: Exercise, caloric restriction, and adequate sleep naturally support NAD+ levels
• Quality: Choose pharmaceutical-grade NAD+ from reputable compounding pharmacies
• Monitoring: Regular assessment of energy levels, sleep quality, and overall well-being